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Select the Right Sanitary Design for your Process

Compare Exergy’s Sanitary Shell & Tube and Tube-in-Tube heat exchangers to find the best fit for your application requirements

Applications

Bioprocessing Equipment

Provides precise heating and cooling for bioreactors, fermenters, and other critical processing equipment.

Purified Water & WFI Systems

Supports pharmaceutical water systems with reliable temperature control and hygienic performance.

CIP & SIP Processes

Delivers dependable heat transfer for clean-in-place and steam-in-place operations while maintaining sanitary integrity.

Product Heating & Cooling

Maintains precise product temperatures during formulation, transfer, and production to ensure consistent quality and process control.

Vaccine & Biologics Manufacturing

Supports temperature-sensitive pharmaceutical and biologic production with hygienic, validated heat transfer solutions.

Filling & Packaging Systems

Provides reliable thermal control for aseptic filling, packaging, and downstream processing operations where product integrity is essential.

Compare Sanitary Shell & Tube and Tube-in-Tube

Sanitary Shell & Tube

Sanitary Shell & Tube

Industry-standard sanitary heat exchanger design for pharmaceutical and hygienic applications where compact efficiency, cleanability, and proven performance matter most.

  • Ideal for WFI, CIP/SIP, and clean utility systems
  • Compact and easy to integrate into skids and OEM equipment
  • Available with double tubesheet for added contamination protection
  • Strong fit for standard sanitary processes with stable operating conditions
View Shell & Tube Page
Sanitary Tube-in-Tube

Sanitary Tube-in-Tube

Thermally flexible sanitary design suited for processes with large temperature differentials and conditions that can create stress in more rigid heat exchanger configurations.

  • Independent inner and outer tubes expand and contract separately
  • Reduces thermal stress and supports long-term mechanical integrity
  • Low hold-up volume and smooth, cleanable flow paths
  • Better fit for dynamic or more demanding thermal processes
View Tube-in-Tube Page

Sanitary Design Comparison

Match your process conditions to the right sanitary design.

Criteria Sanitary Shell & Tube Sanitary Tube in Tube
Design
Multi-tube bundle within a shell
Concentric tube-in-tube design
Heat Transfer Capacity
High-duty thermal performance
Efficient low-flow heat transfer
Pressure Capability
High pressure
Very high pressure
Temperature Difference Handling
Best for moderate ΔT
Best for large ΔT
Flow Rate
Medium to high flows
Low flows
Cleanability
CIP/SIP compatible
CIP/SIP compatible
Drainability
Fully drainable
Fully drainable
Footprint
Compact for high duties
Ultra-compact
Typical Applications
WFI, biotech, food & beverage
Point-of-use, sampling, precision cooling
Key Benefit
Maximum thermal performance
Precise temperature control

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